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Gut microbiome and pain

Our group, as part of the Alan Edwards Centre for the Research Of Pain, has focused much research effort on exploring the link between the gut microbiome and chronic pain. We were the first to show that the gut microbiome is changed in individuals with fibromyalgia, and that these changes could explain some of the symptoms. You are invited to read the full article.

Woman in Pain
What is Fibromyalgia?

Fibromyalgia is a medical condition, which affects many lives. Patients affected by fibromyalgia suffer from chronic pain which involves different body parts: shoulders, arms, upper and lower back. In addition patients often feel tired, even after a night sleep, waking up unrefreshed. Many patients find it difficult to concentrate, and to be physically active.

These symptoms have a serious negative effect on patients' quality of life, academic achievements, daily function and mood.

Our Study
Study Question

We're looking for a link between fibromyalgia and the patients' microbiome, i.e. the germs living in our body. 

Study Procedure

You will be invited for a clinic visits, where you will be examined by a physician expert in fibromyalgia.  Then, you will give a urine, a saliva and a blood sample. At home, you will give a stool sample, which will be thoroughly analysed.

What is this study about?

The study will take place at the Alan Edwards Pain Management Unit, at Montreal General Hospital.

In this study we will look into the gut, urine and mouth bacteria (germs) of patients with fibromyalgia.

A second study site is available at the West Island rheumatology clinic, Pointe-Claire.

Who may join the study?

We're recruiting four groups of participants:

1. Women aged 30-60 years who have fibromyalgia.

2. Healthy women aged 30-60 years who are first-degree relatives (i.e. mother, sister or daughter) of a woman with fibromyalgia participating in our study.

3. Healthy women and men who live in the same house with a fibromyalgia patient participating in our study.

4. Healthy women aged 30-60.

(Since the gut bacteria are influenced by many factors, like age, gender and ethnicity, we limit the gender and age of participants in the study groups.)

What will the study include?

The study will include two clinic visits, filling-in a diet questionnaire and giving one stool sample (at home).

During the first clinic visit, participants will be examined by a leading fibromyalgia expert, will undergo a thorough evaluation, will give a urine, saliva and blood sample, and will be given a stool sample kit.

At home participants will fill-in a dietary questionnaire, give a stool sample. 

During the second visit, participants will deliver their stool sample and their dietary questionnaires will be reviewed.

That's all!

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